-The exploration of different cutoffs of glucocorticoid dose using metabolomics
-A cut off between physiological replacement and pharmacological therapy (based on prednisolone equivalent dose)
– some researchers said that the physiological level of glucocorticoids is 2.5 mg prednisolone equivalent daily , and patients receiving glucocorticoids treatment above 5 mg prednisolone equivalent daily should start having bisphosphonate in order to avoid osteoporosis. Some side effects such as hypertension, insulin resistance etc.. might appear when a patient has > 7.5 mg prednisolone equivalent daily, other side effects such as infectious diseases due to deterioration in immune system appears when the dose exceeds 10 mg daily
– the cutoffs above were determined based on clinical and pharmacological studies, what I want to examine in this paper is The ability of metabolomics to discriminate at some but not other cutoffs
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